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KDM5-C70 was used at 1-10 µM in vitro and cellular assays
Signifor ditrifluoroacetate
Smiles: NC1=CC=CC=C1NC(=O)C1=CN=CC=N1
Formula: C19H20N3NaO6S
Smiles: CC1(N)CCN(CC1)C1=CC=CN=C1NC(=O)C1=NC(=CN=C1N)C1=NC=CC=C1C(F)(F)F
Bardoxolone (methyl) noprofen KDM5-C70 was used at 1-10Bardoxolone methyl (also known as RTA 402 and CDDO methyl ester) is an orally available first in class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Bardoxolone methyl is currently being developed by Reata Pharmaceuticals, Inc. in partnership with Abbott
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